The DARE Foundation is at the forefront of revolutionizing healthcare through the power of digital technology. Our mission is to foster a paradigm shift in healthcare culture, moving from a disease-focused model to one that prioritizes lifelong prevention and community engagement. By harnessing the latest in digital innovations—such as artificial intelligence, high-performance computing, big data analytics, wearable devices, and digital twins—we aim to significantly enhance the speed, accuracy, and effectiveness of preventive healthcare. Our vision is to position Italy as a global leader in digital prevention. This involves creating a connected, multidisciplinary knowledge community that not only develops but also shares innovative solutions across technical, ethical-legal, and organizational domains. Through the DARE initiative, we are committed to integrating and optimizing the use of digital technologies in forecasting, surveillance, early detection, and response to health-related conditions, thereby improving public health outcomes across the lifespan. The foundation coordinates a wide-reaching initiative that spans research, innovation, and stakeholder participation to systematize knowledge and technological solutions essential for digital preventive healthcare. By focusing on data governance, advanced analysis tools, and the promotion of interoperability and evidence-based prevention, we support the national health system in adopting recommendations, guidelines, and best practices at all levels of prevention. DARE's implementation strategy is built around a hub-and-spoke model, engaging a diverse network of partners from universities to private companies, and impacts a broad spectrum of society by optimizing healthcare services, promoting healthier lifestyles, and contributing to economic savings in healthcare expenditure. Ultimately, our goal is to foster a culture that embraces digital technologies for preventive health, enhancing the well-being and quality of life for people in Italy and beyond.